Urolithin A yog dab tsi?

urolithin A yog dab tsi?

Urolithin Ayog ib qho hnyuv metabolite ntawm ellagic acid nrog antioxidant thiab tiv thaiv kev loj hlob. IC50 qhov tseem ceeb ntawm inhibiting T24 thiab cacO-2 cell loj hlob yog 43.9 thiab 49 μM.

Lub luag haujlwm ntawm Urolithin A yog dab tsi?

1. Urolitin A txo cov leeg nqaij atrophy hauv cov neeg laus

Urolitin A txhim kho cov leeg nqaij, raws li Kev Tshawb Fawb Kev Tshawb Fawb tshiab. Urolitin A ntxiv dag zog rau cov nqaij ntshiv ntawm cov leeg pob txha thiab txhim kho ob txhais tes thiab ob txhais ceg.

2. Pab kom poob phaus

Tsis tsuas yog urolitin A tiv thaiv cov leeg, kev tshawb fawb tsis ntev los no tau pom tias urolitin A yeej cuam tshuam cov cellular lipid metabolism thiab rog ntau lawm. Nws txo qis triglyceride tsub zuj zuj thiab fatty acid oxidation, nrog rau kev qhia ntawm cov noob muaj feem xyuam rau cov rog ntau lawm.

3. Urolitin A activates mitochondrial autophagy

Urolitin A kev tiv thaiv cov leeg nqaij tsis ntev los no tsuas yog nrhiav pom, thiab cov kev tshawb fawb yav dhau los tau tsom mus rau mitochondria, tshwj xeeb tshaj yog mitochondrial autophagy. (Mitochondrial autophagy yog hais txog kev xaiv tshem tawm ntawm mitochondria puas los ntawm autophagosome)

UA tuaj yeem qhib mitochondrial autophagy los ntawm ntau txoj hauv kev, xws li ua kom cov enzymes txhawb mitochondrial autophagy, tswj txoj hauv kev mitochondrial autophagy, thiab txhawb kev tsim autophagosome.

4. Anti-inflammatory teebmeem

Ntawm tag nrho cov qauv kho mob ntawm UA, muaj ib qho kev cuam tshuam ntawm kev txo qis cov lus teb.

Cov nyhuv no tau pom thawj zaug hauv cov nas uas muaj kab mob enteritis, qhov twg ob qho tib si mRNA thiab cov protein ntau ntawm cov inflammatory marker cyclooxygenase-2 raug txo.

Lwm cov cim ntawm o, xws li proinflammatory yam thiab qog necrosis, kuj tau pom tias yuav txo qis rau qib sib txawv raws li kev tshawb fawb ntxiv.

Cov tshuaj tiv thaiv kab mob ntawm UA yog multifaceted. Ua ntej, UA muaj ntau nyob rau hauv txoj hnyuv, yog li cov kab mob plab hnyuv yog qhov zoo tshaj plaws. Xws li mob enteritis, ulcerative colitis, thiab txawm mob qog noj ntshav.

Qhov thib ob, UA ua ntau tshaj li kev tiv thaiv kab mob hauv plab, vim tias nws txo cov ntshav qab zib tag nrho ntawm cov kab mob inflammatory. Hauv txoj kev xav, UA tuaj yeem ua lub luag haujlwm hauv txhua yam kab mob.

5. Txhim kho cov kab mob metabolic

Qhov tseeb, cov tshuaj tiv thaiv kab mob ntawm urolitin A thiab kev ua haujlwm ntawm mitochondrial autophagy twb tau zoo heev hauv kev txo cov tsos mob ntawm cov kab mob metabolic.

Tab sis nws kuj muaj cov txiaj ntsig zoo, uas yog txhawm rau txhim kho oxidative kev nyuaj siab, tshem tawm cov dawb radicals, inhibiting oxidase enzymes, thiab txhim kho cellular antioxidant / qhov chaw. Ntau tus kws kho mob ntseeg tias cov txiaj ntsig kev noj qab haus huv no yog vim UA cov tshuaj antioxidant.

Qhov no yog qhov tseem ceeb hauv kev kho mob vim tias kev laus thiab cov kab mob feem ntau muaj hnub nyoog muaj feem cuam tshuam nrog kev mob qis qis thiab kev ntxhov siab oxidative.

Thaum oxidative kev nyuaj siab thiab o raug suppressed, yuav luag tag nrho cov hnub nyoog cov kab mob, xws li neuroinflamation, kab mob plawv thiab kab mob metabolic, txhim kho.

Yuav ua li cas ntxiv rau Urolithin A?

Peb tsis tuaj yeem tau txais urolitin A ncaj qha los ntawm cov khoom noj, tab sis nws tuaj yeem ntxiv nws cov precursor ellagic tannin.

Cov khoom noj uas muaj ellagic acid thiab ellagic tannins muaj xws li pomegranate, raspberries, blueberries, blackberries, walnuts, pistachios, pecans, thiab ib co teas thiab cov laus wines thiab ntsuj plig.

Tsis tshua muaj qab zib blackberries thiab blueberries yog ketogenic tus phooj ywg, thiab txiv ntseej kuj zoo.

Tsis tas li ntawd, nws tsis yog tsuas yog cov khoom siv raw uas txiav txim siab txog bioavailability ntawm urolixin A, tab sis kuj muaj cov kab mob hauv plab hnyuv, thiab nws nyuaj rau hais tias cov nroj tsuag twg muaj txiaj ntsig, tsis paub cov txiaj ntsig.

Thaum peb tuaj yeem muab tauUrolithin Anrog tus nqi zoo heev, yog tias koj xav tau, tsuas yog tiv tauj peb dawb los ntawm email:info@haozbio.com