Txoj Kev Siv Thiab Synthesis ntawm Loratadine
Antiallergic tshuaj
Loratadine yog ib qho tshuaj tiv thaiv kab mob uas feem ntau siv, koom nrog rau tiam thib ob ntawm kev ua yeeb yam ntev tricyclic antihistamines. Nws muaj qhov pib sai, muaj zog, thiab tsis muaj cov tshuaj hormones. Lub cev absorbs thiab metabolizes nquag nquag desloratadine, uas sib tw inhibits histamine H1 receptor thiab suppresses histamine induced hypersensitivity cov tsos mob. Nws tsis muaj qhov tseem ceeb anticholinergic lossis central inhibitory teebmeem. Clinically siv los txo cov tsos mob ntsig txog kev tsis haum rhinitis, xws li txham, qhov ntswg, thiab khaus qhov ntswg, nrog rau qhov muag khaus thiab kub hnyiab. Nws kuj yog siv los txo cov tsos mob ntawm tus mob urticaria thiab lwm yam kab mob ntawm daim tawv nqaij. Toxicology: Tsiaj thwmsim tsis muaj cov teebmeem mutagenic lossis teratogenic. Cov kev phiv tshwm sim muaj xws li mob taub hau, tsaug zog, qaug zog, qhov ncauj qhuav thiab qhov muag tsis pom kev, txo qis lossis nce ntshav siab, palpitations, syncope, hyperkinesia, lub siab hloov pauv, jaundice, kab mob siab, daim siab necrosis, plaub hau poob, qaug dab peg, lub mis loj, erythema multiforme, thiab systemic hypersensitivity tshwm sim. Kev sib cuam tshuam ntawm cov tshuaj: Cov tshuaj uas cuam tshuam kev ua haujlwm ntawm daim siab tshuaj metabolism enzymes tuaj yeem ua rau cov metabolism hauv cov khoom no qeeb, xws li itraconazole thiab ketoconazole. Kev noj 400mg ntawm ketoconazole txhua hnub tuaj yeem ua rau cov ntshav siab ntau ntawm cov khoom no thiab nws cov metabolite nquag, decarboxyethyl loratadine, tab sis tsis muaj kev hloov pauv ntawm electrocardiogram. Ua ke nrog cov tshuaj tua kab mob macrolide, cimetidine, theophylline, thiab lwm yam tshuaj tuaj yeem cuam tshuam cov metabolism ntawm loratadine.
Txoj kev tsim khoom
Dissolve 4- (8-chloro-5, 6-diamino-11H-benzocycloheptanopyridin-11 subunit) -1-methylpiperidine hauv toluene, ntxiv ethyl chloroformate dropwise, ua kom tiav cov tshuaj tiv thaiv, ntxiv dej, cais cov benzene txheej, ntxuav nrog dej, qhuav, thiab mloog zoo nyob rau hauv lub siab txo kom tau ib tug oily khoom, tsau nrog ether, thiab recrystallize kom tau loratadine.
Lub hom phiaj
Cov tshuaj tiv thaiv histamine muaj kev xaiv siab rau peripheral paj hlwb H1 receptors, muaj zog, thiab ntev ntev. Nws yog ib tug ntev-acting tricyclic antihistamine uas sib tw inhibits histamine H1 receptor thiab inhibits kev tsis haum tshuaj tshwm sim los ntawm histamine. Tsis muaj qhov tseem ceeb anticholinergic lossis central inhibitory cuam tshuam. Siv los txo cov tsos mob ntsig txog kev tsis haum rhinitis thiab txo cov tsos mob ntawm tus mob urticaria thiab lwm yam kab mob ntawm daim tawv nqaij.
Kev siv thiab ntau npaum li cas
Vim muaj ntau hom tshuaj thiab cov lus qhia tshwj xeeb, thov ua tib zoo nyeem phau ntawv qhia tshuaj lossis ua raws li cov lus qhia kho mob rau kev siv thiab ntau npaum li cas.
Kev phiv tshuaj
(1) Tsawg. Qee zaus qhov ncauj qhuav, mob taub hau, thiab lwm yam.
(2) Qee lub sij hawm lub siab ua haujlwm tsis zoo, jaundice, kab mob siab, thiab daim siab necrosis yuav tsum tau txo qis hauv cov neeg mob uas lub siab ua haujlwm tsis zoo.
(3) Tsis tshua muaj erythema multiforme thiab kev tsis haum tshuaj.
Contraindication
Txwv tsis pub rau cov neeg uas ua xua rau cov khoom no. Tsis pom zoo rau cov menyuam yaus hnub nyoog qis dua 2 xyoos. Cov poj niam cev xeeb tub thiab lactating yuav tsum siv ceev faj.
Cov teeb meem xav tau kev saib xyuas
1. Cov neeg mob uas muaj lub siab lossis lub raum tsis zoo, cov menyuam yaus hnub nyoog qis dua 2 xyoos, cov poj niam cev xeeb tub, thiab cov poj niam cev xeeb tub yuav tsum siv ceev faj.
2. Yog tias loratadine txuas ntxiv siv ntau tshaj ib hlis, cov tshuaj ntau yam yuav tsum tau hloov los tiv thaiv cov tshuaj tiv thaiv.
3. Cov neeg haus dej haus cawv thiab cov neeg uas nquag noj tshuaj tiv thaiv kab mob yuav tsum ntxiv dag zog rau lawv txoj kev soj ntsuam rau qhov ua rau qaug zog qaug zog lossis lwm yam kev cuam tshuam hauv nruab nrab thaum pib siv loratadine, thiab ua tib zoo saib xyuas cov tshuaj, lossis tsis txhob haus cawv thiab txwv tsis pub cov tshuaj diazepam thaum noj tshuaj. lub sij hawm.
4. Kwv yees li ntawm 48 teev ua ntej kuaj cov tawv nqaij, loratadine yuav tsum tau txiav tawm vim tias cov tshuaj tiv thaiv kab mob tuaj yeem tiv thaiv lossis txo cov tawv nqaij zoo rau cov tshuaj tiv thaiv siv.
