Qhov Tseem Ceeb Ntawm Lidocaine

Dab tsi yoglidocaine?

Nws yog ib qho tshuaj loog hauv zos sodium channel blocker uas muaj cov teebmeem membrane-stabilizing thiab siv tawm tsam ventricular arrhythmias; Nws kuj muaj kev tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, ua lub luag haujlwm tiv thaiv kab mob hauv ntau qhov sib txuas ntawm cov lus teb inflammatory, nws qhov tseem ceeb inhibition ntawm inflammatory teb, mob ntsws raug mob, anti-cancer tshuaj sensitization nyhuv, antibacterial, feem ntau siv nyob rau hauv kev kho mob hlwb tiv thaiv. thiab txo qis kev paub tsis meej tom qab ua haujlwm (POCD) thiab lwm yam.

Antiarrhythmic teebmeem ntawm lidocaine:

Ridoca xaiv ua rau Purkinje fibroblasts thiab ventricular myocytes vim yog IB cov tshuaj antiarrhythmic, uas ua rau qeeb ntawm 4-theem depolarizing tus nqi, txo qhov tsis siv neeg ntawm Purkinje fibers, txhawb K ntxiv efflosion, shorens lub sij hawm ntawm kev ua muaj peev xwm thiab prolongs cov txiaj ntsig. lub sij hawm refractory. Nws yog feem ntau siv rau kev tiv thaiv thiab kev kho mob ntawm ventricular arrhythmia. Lidocaine tuaj yeem ua rau lub plawv dhia qeeb, inhibit cardiac contractility thiab txo qis cov zis. Lidocaine tau siv rau hauv kev kho mob antiarrhythmic rau lub sijhawm ntev thiab muaj kev paub ntau dua. Nyob rau hauv lub ntsej muag ntawm ventricular arrhythmia, cov kws kho mob feem ntau siv lidocaine los tswj nws, uas muaj txiaj ntsig zoo thiab kev nyab xeeb.

Lidocainetiv thaiv kom tsis txhob muaj cov kab mob inflammatory ntau dhau:

Ntau cov kev tshawb fawb tau pom tias lidocaine muaj kev tiv thaiv zoo thiab kho mob ntawm qhov mob tshwm sim los ntawm kev raug mob lossis endotoxin. Lidocaine yog ib tug stabilizer daim nyias nyias uas inhibits adhesion thiab aggregation ntawm neutrophil granulocytes (PMN), txo qhov tso tawm ntawm oxygen dawb radicals thiab proteolytic enzymes, stabilizes cell membranes, tswj cytokines, thiab inhibits ntau inflammatory teb. Cov inflammatory mediators LB4 thiab Interleukin 1 (IL-1) yog ob qho tib si muaj zog PMN chemoattractant, inducing PMN los khi, pellet, exudate, thiab tsim superoxide, thiab koom tes nrog prostaglandin E2 kom vascular permeability. Hauv vitro, monocytes tau tsim nrog ntau qhov sib txawv (2-20} mol / L) ntawm lidocaine, uas cuam tshuam qhov tso tawm LB4 thiab IL-1 . Cov qib micromolar concentration ntawm lidocaine tuaj yeem cuam tshuam qhov tso tawm ntawm histamine los ntawm leukocytes, mast cells thiab basophils, qhia tias lidocaine tuaj yeem cuam tshuam qhov kev tso tawm ntawm qee qhov tseem ceeb inflammatory mediators. Nws ua raws li kev tiv thaiv kab mob, yog li feem ntau cov dej tsis muaj dej khov muaj nws kom txo tau cov cell nkag mus thiab txhawb cov cell dormancy kom sai li sai tau.

Hauv daim ntawv thov kev kho mob, ntau cov kev tshawb fawb tau pom tias cov tshuaj intraoperative intravenous infusion ntawm lidocaine tuaj yeem tswj cov neeg mob lub cev tsis muaj zog thiab ua kom cov neeg mob rov qab ua haujlwm. Muaj cov teeb meem xws li phlebitis nyob rau hauv tus txheej txheem ntawm PCIA, thiab ntxiv lidocaine rau hauv cov hlab ntsha analgesia twj tso kua mis tuaj yeem tiv thaiv phlebitis. Perioperative intravenous txhaj ntawm low-dose lidocaine tuaj yeem txo qhov mob tshwm sim los ntawm kev phais thiab txo cov amide hauv zos tshuaj loog uas nquag siv hauv kev phais. Cov kev tshawb fawb tau pom tias nws muaj kev tiv thaiv kab mob, thiab perioperative intravenous infusion ntawm lidocaine tuaj yeem txo qhov mob tom qab phais, txo kev siv opioid analgesics, txo qhov mob, ua kom rov qab ua haujlwm ntawm plab hnyuv thiab ua kom ntev ntawm cov neeg mob nyob hauv tsev kho mob.

Antibacterial kev ua ntawm lidocaine

Nws tau raug tshaj tawm tias lidocaine tuaj yeem cuam tshuam qhov adhesion thiab chemotactic txheej txheem ntawm granulocytes, thiab tuaj yeem cuam tshuam cov kab mob intracellular. Cov kev tshawb fawb tau pom tias cov tshuaj loog hauv zos inhibit qhov kev loj hlob ntawm cov cell ntawm E. coli thiab ua rau lub cev tawm ntawm cov ntsiab lus ntawm tes thiab cuam tshuam rau nws txoj kev ua pa. Hauv cov ntsiab lus, kev siv lidocaine rau cov tshuaj loog epidural lossis lub sijhawm ntev postoperative analgesia tuaj yeem tiv thaiv kev loj hlob ntawm cov kab mob hauv qhov chaw epidural thiab catheter, uas muaj kev nyab xeeb thiab ua tau. Cov txheej txheem ntawm cov tshuaj tua kab mob ntawm cov tshuaj loog hauv zos xws li lidocaine tseem tsis paub meej. Nws yog qhov ua tau tias kev sib cuam tshuam ntawm cov tshuaj loog hauv zos thiab cov tshuaj macromolecular ntawm cov kab mob hauv cov kab mob los yog cov cell membrane cuam tshuam nrog cov cell membranes ntawm eukaryotes thiab prokaryotes, hloov kev ua haujlwm ntawm cell membranes, thiab ua rau kev tuag lossis kev loj hlob inhibition ntawm cov kab mob.

Qee cov kev tshawb fawb tau pom tias cov tshuaj tua kab mob ntawm lidocaine ({{0}}}.5 feem pua ​​-1.0 feem pua ​​) thiab bupivacaine (0.125 feem pua ​​{{6 }}.25 feem pua ​​) yog pom tseeb ntawm cov tshuaj kho mob ntau, thiab cov tshuaj tua kab mob zoo li nce ntxiv nrog kev nce siab. Ntxiv mus, 1 feem pua ​​​​lidocaine tuaj yeem suav hais tias muaj cov nyhuv bacteriostatic dua li 0.125 feem pua ​​​​bupivacaine.

Lub hlwb tiv thaiv cov teebmeem ntawm lidocaine

Lidocaineyog ib qho yooj yim hla cov ntshav-hlwb barrier thiab muaj membrane stabilization. Thaum lidocaine tuaj yeem txo qis hauv lub hlwb thiab cov hlab ntsha loj, nws tuaj yeem txo qis intracellular Na ntxiv thiab Ca2 ntxiv cov concentrations los ntawm kev thaiv Na plus, K ntxiv thiab Ca2 ntxiv raws, txo ATP noj, ua lub luag haujlwm tiv thaiv hauv cov hlab ntsha hypoxic, txo K. ntxiv rau cov dej tawm, inhibit qhov tso tawm ntawm excitatory amino acids thiab oxygen dawb radicals kom txo tau cov ntaub so ntswg puas hlwb thiab txhim kho cerebral ntshav txaus. Ua si lub hlwb tiv thaiv lub luag haujlwm. Cov kev tshawb fawb tau pom tias lidocaine tuaj yeem tsis tsuas yog txo qis hauv lub hlwb thiab cov hlab ntsha loj hauv lub cev, tab sis kuj nthuav dav cov hlab ntsha hauv lub hlwb ntawm qhov chaw raug mob, uas tuaj yeem txo qis cov pa oxygen metabolism, txo cov anaerobic colysis, tswj cov ntshav qab zib kom ruaj khov. , thiab tsis ncua lub sijhawm rov qab ua haujlwm tom qab.

Xav paub ntau ntxiv txog rauLidocaine, tsuas yog tiv tauj peb dawb ntawm email:info@haozbio.com.