Mupirocin Ointment tseem siv tau zoo li no !!

Kev taw qhia luv luv

Mupirocin, tseem hu ua Pseudomonas A, yog qhov zoo tshaj plaws ntawm daim tawv nqaij tiv thaiv kab mob uas tau qhia rau lub khw hauv xyoo 1985 los ntawm GlaxoSmithKline hauv qab lub npe lag luam "Bactroban". FDA tau pom zoo cov tshuaj siv rau hauv Tebchaws Meskas xyoo 1987, thaum Tuam Tshoj pom zoo tsim thiab muag cov tshuaj los ntawm SinoSmithKline hauv 1993. Mopirocin feem ntau yog siv los tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij los ntawm Gram positive cocci.

Qhov taw qhia
Mopirocin feem ntau yog siv los tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij los ntawm Gram zoo cocci, xws li cov kab mob hauv daim tawv nqaij xws li pustulosis, furuncles, folliculitis, thiab lwm yam kab mob ntawm daim tawv nqaij xws li eczema coinfection, ulcer coinfection, thiab qhov txhab nyiaj npib. Lub ntsiab mechanism ntawm antibacterial nyhuv ntawm mupirocin yog nws inhibition ntawm protein synthesis nyob rau hauv cov kab mob.
Tshuaj tua kab mob
Cov khoom siv raw ntawm Baiduobang ointment tsim los ntawm cov tuam txhab lag luam paub zoo SinoSmithKline hauv Suav teb yog mupirocin. Cov khoom no yog ib hom tshuaj tua kab mob tshiab thiab cov tshuaj metabolic uas tsim nyob rau hauv kab lis kev cai nruab nrab ntawm Pseudomonas fluorescens, uas yog Pseudomonas A. Feem ntau los ntawm reversibly khi rau isoleucine hloov RNA synthase, nws tiv thaiv isoleucine incorporation, terminates protein synthesis uas muaj isoleucine hauv hlwb, thiab ua rau cov kab mob tuag. Nws muaj cov nyhuv inhibitory ntawm tsawg concentrations thiab cov nyhuv bactericidal ntawm siab concentrations. Cov rhiab heev rau ntau yam Gram zoo cocci ntsig txog cov kab mob ntawm daim tawv nqaij, tshwj xeeb tshaj yog Staphylococcus aureus (xws li tshuaj tiv thaiv Staphylococcus aureus) thiab Streptococcus pyogenes; Nws kuj tseem siv tau rau Listeria monocytogenes thiab Erythrocytogenes; Nws feem ntau tsis hnov ​​​​qab cov kab mob gram-tsis zoo, tab sis muaj qee yam tshuaj tua kab mob ntawm qee cov kab mob gram-tsis zoo, xws li Escherichia coli, Neisseria, Haemophilus influenzae thiab Neisseria gonorrhoeae; Tsis rhiab rau feem ntau cov kab mob anaerobic thiab ib txwm tawv nqaij microbiota; Tsis tshua muaj txiaj ntsig tawm tsam fungi. Qhov tshwm sim ntawm in vitro tshuaj resistant variants yog tsawg heev. Tom qab siv cov tshuaj no rau ntawm daim tawv nqaij, nws tuaj yeem nkag mus rau hauv qab ntawm stratum corneum, tab sis qhov nqus tau qis heev. Kev khi tus nqi nrog tib neeg cov ntshav cov protein yog 95 feem pua. Tom qab nqus tau, nws tuaj yeem hloov pauv sai sai rau hauv cov tshuaj tsis muaj zog monosporic acid, uas tau tawm los ntawm lub raum. Qhov tsawg kawg nkaus inhibitory concentration ntawm feem ntau rhiab Staphylococcus yog 0 01 ~ 0.25 mg/L, rhiab heev streptococcus 0.06 ~ 0.5 mg/L, thiab Listeria monocytogenes 8 mg/L. Hauv kev sim vitro, cov khoom no muaj txiaj ntsig zoo nyob rau hauv acidic tej yam kev mob ntau dua li nyob rau hauv alkaline tej yam kev mob. Thaum tib neeg cov ntshav muaj nyob, nws cov dej num txo qis los ntawm 1/10-1/20. Tam sim no, hauv kev kho mob hauv Suav teb, mupirocin feem ntau yog siv los kho ntau yam kab mob ntawm daim tawv nqaij kis los ntawm Staphylococcus aureus thiab Streptococcus: thawj kab mob ntawm daim tawv nqaij, xws li pustulosis, folliculitis, thiab furuncle; Cov kab mob thib ob ntawm daim tawv nqaij, xws li eczema, atopic dermatitis, daim tawv nqaij rwj, qhov txhab phais, kub hnyiab me me, thiab kev raug mob ntawm daim tawv nqaij; Lwm txoj hauv kev kuj tseem siv tau los tiv thaiv kev kis kab mob hauv qhov txhab me me, incisions, thiab lwm yam kab mob tsis muaj menyuam.

Staphylococcus aureus thiab Streptococcus yog cov kab mob colonizing ntawm daim tawv nqaij ib txwm ntawm tib neeg lub cev, thiab qhov ntswg kab noj hniav yog qhov chaw tseem ceeb colonizing. Staphylococcus aureus nyob rau hauv lub qhov ntswg kab noj hniav tuaj yeem txav mus rau ntawm daim tawv nqaij, kab mob ua pa, phais phais, thiab lwm qhov chaw, ua rau muaj kab mob. Kev tua cov kab mob endogenous Staphylococcus aureus nyob rau hauv lub qhov ntswg kab noj hniav yog qhov zoo los txo qis qhov tshwm sim ntawm daim tawv nqaij, kab mob ua pa thiab kab mob phais thiab tiv thaiv qhov tshwm sim ntawm lub tshuab ua pa cuam tshuam nrog mob ntsws.
Vim muaj cov qauv anatomical tshwj xeeb ntawm lub qhov ntswg kab noj hniav, nws feem ntau pom zoo kom siv tshuaj tua kab mob tshuaj tua kab mob kom tshem tawm cov kab mob colonized. Mopirocin ointment zoo li yog qhov kev xaiv zoo tshaj plaws raws li cov tshuaj nquag siv los kho cov kab mob ntawm daim tawv nqaij xws li Staphylococcus aureus thiab Streptococcus. Cov neeg ua haujlwm kho mob ceev faj yuav pom tau tias "cov khoom no tsuas yog siv rau ntawm daim tawv nqaij thiab yuav tsum tsis txhob siv rau ntawm daim tawv nqaij xws li lub qhov ntswg, qhov muag, thiab qhov ncauj" thaum nyeem cov lus qhia ntawm mupirocin ointment. Cov tshuaj mupirocin puas tuaj yeem siv rau ntawm qhov ntswg?
Nws tau pom nyob rau ntawm FDA lub vev xaib tias muaj ob hom tshuaj Mupirocin hauv Tebchaws Meskas. Ib qho yog Mupirocin Ointment, tshwj xeeb yog tsim los rau cov kab mob ntawm daim tawv nqaij, uas yog cov khoom siv hauv tsev ntawm Mupirocin ointment; Lwm hom yog Mupirocin Nasal Ointment, tshwj xeeb tsim los tshem tawm cov kab mob zoo xws li Staphylococcus aureus colonized hauv qhov ntswg kab noj hniav. Puas muaj peev xwm siv mupirocin ointment es tsis txhob siv tshuaj pleev qhov ntswg thaum tsis muaj cov tshuaj pleev qhov ntswg tshwj xeeb hauv Suav teb? Kuv tau tshawb nrhiav cov ntaub ntawv thiab pom tias twb muaj ntau cov lus ceeb toom nyob rau hauv Suav teb uas siv mupirocin ointment siv rau lub qhov ntswg kab noj hniav rau colonization muaj kev nyab xeeb thiab zoo. Yog li ntawd, cov neeg mob uas xav tau kev colonization tuaj yeem sim siv nws.
Txawm li cas los xij, raws li nws tau siv dhau cov lus qhia, tus neeg mob yuav tsum tau ceeb toom txog lub hom phiaj ntawm cov tshuaj thaum siv, thiab yog tias tus neeg mob muaj qhov tsis xis nyob, nws yuav tsum txiav tam sim ntawd. Nyob rau tib lub sijhawm, nco ntsoov cov neeg mob tsis txhob xaiv cov tshuaj kho qhov ntswg ntawm lawv tus kheej thiab siv nws raws li tus kws kho mob cov lus qhia.