Tirzepatide

1.Product lub npe: Tirzepatide
2.Appearance: Dawb hmoov
3.Molecular Formula: /
4.Molecular Luj:0
5. CAS Nr.: 1078-21-3
6.Purity: 99%
7.Test Method: HPLC
8.Kev Them Nyiaj: TT, Western Union, Paypal, Pingpong, Xtransfer, ect.
9.Shelf Life: 2 xyoos

Xa kev nug Tsham tam sim no

Hauj lwm lawm

Khoom Taw Qhia

Tirzepatide yog ib qho tshiab glucagon-zoo li peptide -1 receptor (GLP-1) thiab qabzib-dependent insulinotropic polypeptide (GIP, aka: gastric inhibitory polypeptide) dual-receptor agonist, muab ib zaug ib lub lim tiam. GLP-1 thiab GIP muaj nyob rau hauv enteroglucagon, uas yog polypeptide secreted los ntawm mucous daim nyias nyias ntawm lub plab zom mov ntawm tib neeg lub cev. tus qub tuaj yeem khi nrog cov receptor ntawm pancreatic islet cell thiab GLP-1 thiab GIP yog ob qho tib si enteroglucagon, peptides secreted los ntawm mucosa ntawm tib neeg txoj hnyuv. Cov qub tuaj yeem khi rau cov receptors ntawm pancreatic islet hlwb thiab txhawb kev tsim cov tshuaj insulin los tsim cov piam thaj txo qis, nrog rau kev ua kom lub plab zom mov thiab txo qis qab los noj mov, yog li tswj lub cev hnyav; tom kawg muaj peev xwm inhibit qhov tso tawm ntawm gastric acid, pepsin, txhawb kev tso tawm insulin, thiab inhibit gastric peristalsis thiab tshem tawm, uas ua tiav cov teebmeem ntawm GLP-1 agonist. Ntshav qab zib mellitus thiab sawv cev rau cov chav kawm tshiab ntawm cov tshuaj rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus.Translated with DeepL.com (dawb version)

Product Photo thiab ua

Tirzepatide

Khoom Specification

Tirzepatide

Khoom muaj nuj nqi

Tirzepatide sib koom ua ke zoo sib xws rau semaglutide, nrog rau lys sab saw ntawm cov kab ke bearing PEG hloov kho, uas yog ib pab pawg ua haujlwm ntawm peptide, nrog rau kev muaj peev xwm ua kom cov dej solubility ntawm qhov sib lawv liag.Cov thawj physiological muaj nuj nqi ntawm Tirzepatide. yog ib qho ntawm ob agonist ntawm qabzib-dependent insulinotropic polypeptide (GIP) thiab glucagon-zoo li peptide -1 (GLP-1) receptor. Nws tau raug tsim los rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus thiab tau nkag mus rau theem kho mob.Piv nrog DeepL.com (dawb version)

Kev nyab xeeb
Kev nyab xeeb profile ntawm tilpeptide zoo ib yam li lwm cov enteroglucagon analogues. Kev tshuaj xyuas Meta ntawm xya qhov kev sim tshuaj ntsuam xyuas tau pom tias muaj kev cuam tshuam hauv plab hnyuv (xws li xeev siab, raws plab thiab cem quav) tau nce siab nrog tilpeptide piv rau cov placebo, tab sis feem ntau yog me me mus rau nruab nrab. Lwm yam kev phiv tshuaj, tshwj xeeb tshaj yog hypoglycemia tsis pom muaj qhov sib txawv ntawm ob pawg. Txawm li cas los xij, vim lub sijhawm luv luv ntawm kev ua lag luam, qhov kev nyab xeeb tiag tiag tseem yuav tsum tau ua kom pom tom qab kev lag luam.

Cov txiaj ntsig zoo hauv kev txo cov piam thaj thiab poob phaus
Cov kev tshawb fawb SURPASS yog ib qho kev soj ntsuam loj randomized tswj kev sim tsim los ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm tilprotide hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus (T2DM). Ntawm cov no, cov txiaj ntsig zoo siab tshaj plaws tau pom hauv SURPASS-2[1], kev sib piv lub taub hau nrog simethicone, uas piv cov piam thaj txo qis ntawm tilpeptide 5mg (n=470), 1 0mg (n=469), thiab 15mg (n{12}}) nrog simethicone 1mg (n=468). Cov txiaj ntsig tau pom tias piv rau theem pib HbA1c (8.3 ib xees), tilpeptide txo cov neeg kawm 'HbA1c los ntawm qhov nruab nrab ntawm 2.0, 2.2 thiab 2.3 ib xees, piv rau qhov nruab nrab ntawm 1.9 ib xees rau simelglutide, thiab hais txog kev poob phaus, piv rau lub cev qhov hnyav (207 lbs), tilpeptide ua rau qhov hnyav nruab nrab ntawm 17 lbs, 21 lbs thiab 25 lbs rau cov kev kawm, piv rau 13 lbs rau simelglutide. Qhov kev sim no tau pom tias tilprotide tau pom zoo txo qis qabzib thiab poob phaus piv rau semeglutide. Lwm qhov kev tshawb fawb loj tau tso npe rau 2,539 tus neeg laus uas muaj tsawg kawg ib qho teeb meem kev rog rog (tsis suav nrog ntshav qab zib mellitus) thiab lub cev qhov hnyav (BMI) ntau dua lossis sib npaug li 30kg / m2 lossis ntau dua lossis sib npaug li 27kg / m2. Tag nrho cov kev kawm tau randomized nyob rau hauv sib npaug proportions rau tilprotectin 5mg, 10mg, thiab 15mg piv rau cov placebo pawg, thiab cov txiaj ntsig tau pom tias, ntawm 72 lub lis piam, cov pab pawg tau txo qis hauv lub cev hnyav ntawm 16.1kg, 22.2kg, 23.6kg, thiab 2.4. ib kg [2]. Cov nyhuv poob ntawm tilpeptide yog piv rau qhov poob phaus phais.

Khoom siv

Tilpeptide txo kev noj zaub mov, txo lub cev hnyav thiab txo qis adiposity los ntawm kev txo qis calorie kom tsawg thiab tswj kev qab los noj mov. Tsis tas li ntawd, tilpeptide tau pom tias tswj kev siv lipid. Thaum lub Tsib Hlis 2022, tilpeptide tau pom zoo los ntawm US FDA rau kev txhim kho glycemic tswj (raws li kev tswj hwm kev noj haus thiab kev tawm dag zog) hauv cov neeg laus uas muaj ntshav qab zib hom 2, thiab thaum lub Kaum Ib Hlis 2023, cov khoom tau pom zoo los ntawm FDA rau kev tswj xyuas mus ntev. Qhov hnyav (raws li kev noj zaub mov tsis muaj calorie ntau thiab ua kom lub cev muaj zog) hauv rog (BMI Ntau dua lossis sib npaug li 30 kg / m2) lossis cov neeg laus hnyav uas muaj tsawg kawg yog ib qho comorbidity (BMI Ntau dua lossis sib npaug li 27 kg / m2 ). kev ua si).

Tirzepatide