Terazosin

Khoom Taw Qhia

Terazosin tshuaj muaj zog zoo dawb crystals, tsw thiab tasteless, melting point 272.6 ~ 174 degree. 25 degree solubility (mg/m1): methanol 33.7, dej 29.7, 95% ethanol 4.1, 0.1mol/L hydrochloric acid 3,8, chloroform 1.2, acetone 0.{2{{ 30}}}}1. ob peb insoluble hauv hexane. UV nqus dej siab tshaj plaws (0005% dej): 212, 245, 330nm (a65.7, 127.5, 24.0). pKa (0.1mol/L sodium hydroxide) 7.7. UV nqus dej siab tshaj plaws (0.005% dej): 212, 245, 330nm (a65.7, 127.5, 24.0). pKa (0.1mol/L sodium hydroxide) 7.1. Terazosin Hydrochloride: C19H25N5O4 HCl. Crystallized los ntawm isopropanol, hygroscopic. Melting point 278 ~ 279 degree. Soluble hauv dej: 761.2mg / ml. Mob toxicity LD50 nas (mg/kg): 259.3 IV. Terazosin hydrochloride dihydrate: C19H25N5O4?HCl?2H2O[{67}}]. Melting point 271-274 degree . Dissolved nyob rau hauv dej: 24.2 mg/ml.Acute toxicity LD50 txiv neej thiab poj niam nas (mg/kg): 277, 293 IV.Terazosin yog ib tug quinazoline derivative thiab ib tug sib tw thiab hais lus active 1-adrenoceptor antagonist.Terazosin ua los ntawm dilatosin cov hlab ntsha thiab qhib lub zais zis. Terazosin yog siv rau hauv kev tshawb fawb ntawm benign prostatic hyperplasia (BPH) thiab kub siab. Hom phiaj 1-adrenoceptor hauv vitro kev tshawb fawb

 

Product Photo thiab ua

 

Khoom Specification

 

Txoj kev tsim khoom
Furoic acid yog siv los ua raw khoom, chlorinated nrog sulfoxide los tsim furoyl chloride, thiab tom qab ntawd monoacylated piperazine, monoacylated khoom raug txo thiab condensed nrog 4-amino-2-chloro-6, {{3} }dimethoxyquinazoline nyob rau hauv lub xub ntiag ntawm triethylamine kom tau terazosin. Acidification nrog hydrochloric acid nyob rau hauv ethanol muab terazosin hydrochloride uas muaj ob crystalline dej.

Cov lus qhia
Terazosin hydrochloride yog siv rau kev kho mob ntawm benign prostatic hyperplasia. Terazosin hydrochloride kuj tseem siv rau hauv kev kho mob ntshav siab, ib leeg lossis ua ke nrog lwm cov tshuaj tiv thaiv hypertensive xws li diuretics lossis -adrenergic blockers [3].

Dosage thiab Administration
Yog tias terazosin hydrochloride raug txiav tawm rau ob peb hnub, kev kho mob yuav tsum tau rov pib dua nrog kev siv tshuaj thawj zaug.
Benign Prostatic Hyperplasia 1. Thawj koob tshuaj thawj zaug yog 1 mg thaum mus pw. Tus neeg mob yuav tsum tau saib xyuas kom zoo thaum thawj zaug tswj hwm kom tsis txhob muaj cov tshuaj tiv thaiv hypotensive. 2. Kev Kho Mob Cov koob tshuaj yuav tsum tau nce ntxiv mus rau 2mg, 5mg lossis 10mg ib hnub ib zaug kom txog rau thaum kev txhim kho txaus siab ntawm cov tsos mob thiab/lossis cov dej ntws tau tiav. 3. Feem ntau siv koob tshuaj 10mg ib hnub ib zaug. Txuas ntxiv rau 4 mus rau 6 lub lis piam. Nws tsis paub meej tias cov koob tshuaj ntau dua tuaj yeem siv los kho cov neeg mob uas tsis tsim nyog lossis tsis kho nrog 20mg txhua hnub. Yog tias cov tshuaj raug txiav tawm rau ob peb hnub lossis ntev dua, kev kho mob yuav tsum tau rov pib dua siv cov tshuaj thawj zaug. 4.Co-administration Kev saib xyuas tshwj xeeb yuav tsum tau noj thaum koom nrog lwm cov tshuaj tiv thaiv hypertensives, tshwj xeeb tshaj yog calcium channel blocker verapamil, kom tsis txhob muaj qhov hypotension tseem ceeb thiab txo cov koob tshuaj ntawm cov khoom no.
Ntshav siab 1.First Dose Cov koob tshuaj thawj zaug yog 1 mg thaum mus pw. Tus neeg mob yuav tsum tau saib xyuas kom zoo thaum thawj koob tshuaj kom tsis txhob muaj cov tshuaj tiv thaiv hypotensive. 2. Kev Saib Xyuas Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv yuav tsum tau nce qeeb kom txog thaum cov ntshav siab txaus. Cov koob tshuaj pom zoo feem ntau yog 1mg-5mg ib hnub ib zaug; Txawm li cas los xij, qee tus neeg mob tuaj yeem siv tau ntawm 20mg ib hnub. Cov koob tshuaj ntau dua 20 mg tsis tshwm sim ntxiv rau cov ntshav siab, thiab cov koob tshuaj ntau dua 40 mg tsis tau kawm. Ntshav siab yuav tsum tau saib xyuas ntawm cov koob tshuaj. Yog tias cov nyhuv antihypertensive ua tsawg dua tom qab 24 teev ntawm kev tswj hwm, kev siv tshuaj noj ob zaug ib hnub yuav raug txiav txim siab. Yog tias cov tshuaj raug txiav tawm rau ob peb hnub lossis ntev dua, kev kho mob yuav tsum tau rov pib siv thawj zaug kev siv tshuaj. Hauv kev sim tshuaj, kev noj tshuaj thaum sawv ntxov yog nyiam, tshwj tsis yog thawj koob tshuaj thaum mus pw.

Pharmacokinetics
Cov tshuaj yog qhov tseem ceeb kiag li absorbed nyob rau hauv cov txiv neej cov neeg mob. Kev noj tshuaj tam sim tom qab noj mov muaj qhov cuam tshuam tsawg kawg nkaus ntawm qhov nqus, tab sis ncua sij hawm siab kawg ntawm cov ntshav ntshav los ntawm kwv yees li 40 feeb. Hepatic first-pass metabolism ntawm terazosin yog tsawg. Nws peaks kwv yees li 1 teev tom qab noj thiab muaj ib nrab-lub neej ntawm kwv yees li 12 teev. Hauv kev tshawb fawb txog cov nyhuv ntawm lub hnub nyoog ntawm cov tshuaj pharmacokinetics ntawm terazosin, cov ntshav ib nrab-lub neej tau pom tias yog 14.0 thiab 11.4 teev hauv cov neeg mob hnub nyoog 70 thiab 20-39 xyoo, raws li. Plasma protein khi yog 90-94 %. Kwv yees li 40% tawm hauv cov zis thiab kwv yees li 60% hauv cov quav.

 

Khoom siv

Rau kev kho mob ntshav siab thiab txhim kho cov tsos mob ntawm cov zis hauv cov neeg mob uas muaj benign prostatic hyperplasia.

Delivery & Ntim

Peb ib txwm ntim cov PS nrog cov ntawv ci hnab hmoov 1kg / hnab, export nruas 25kg / nruas.

Kuj lees txais kev pabcuam customization raws li koj qhov kev nug.

Raws li kev xa khoom, peb tuaj yeem xa khoom los ntawm courier, los ntawm hiav txwv, los ntawm huab cua, ect.

Xav paub ntau ntxiv thov mus saib cov duab hauv qab no rau kev siv:

 

Yog koj muaj lus nug los yog nug txogTerazosin, thov hu rau peb mail:info@haozbio.com

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