Minocycline Hydrochloride

1.Product lub npe: Minocycline hydrochloride
2.Appearance: Dawb hmoov
3.Molecular Formula: C23H28ClN3O7
4.Molecular Luj: 493.94
5. CAS Nr.: 1078-21-3
6.Purity: 99%
7.Test Method: HPLC
8.Kev Them Nyiaj: TT, Western Union, Paypal, Pingpong, Xtransfer, ect.
9.Shelf Life: 2 xyoos

Xa kev nug Tsham tam sim no

Hauj lwm lawm

Khoom Taw Qhia

Minocycline hydrochloride, tseem hu ua "dimethylaminotetracycline" lossis "memantine", yog ib qho dav-spectrum tetracycline tshuaj tua kab mob. Nws khi rau tRNA, uas yog lub luag haujlwm rau nws cov nyhuv bacteriostatic. Minocycline hydrochloride muaj qhov dav dav ntawm cov tshuaj tua kab mob ntau dua li cov tshuaj zoo sib xws. Vim nws lub neej ib nrab ntev, Minocycline hydrochloride cov ntshav concentration yog ob mus rau plaub npaug ntau dua li lwm cov tshuaj hauv nws chav kawm.
Minocycline hydrochloride yog ib qho tshiab semi-synthetic tetracycline nrog kev ua haujlwm siab, ua haujlwm sai thiab ua haujlwm ntev, thiab nws cov tshuaj tua kab mob zoo ib yam li tetracycline. Tetracycline-resistant Aureus, Streptococcus, thiab Escherichia coli tseem rhiab heev rau cov khoom no. Clinically, nws yog tsuas yog siv rau cov kab mob urinary, kab mob plab, kab mob gynecological, pyoderma, qhov muag thiab pob ntseg, qhov ntswg thiab caj pas kab mob, osteomyelitis thiab hais txog.

Product Photo thiab ua

Minocycline hydrochloride

Khoom Specification

Minocycline hydrochloride

Khoom muaj nuj nqi

Minocycline hydrochloride yog ib qho tshuaj tiv thaiv kab mob ib nrab-synthetic tetracycline uas hla cov ntshav-hlwb barrier.Minocycline hydrochloride yog ib qho hypoxia-inducible factor (HIF-1) inhibitor.Minocycline hydrochloride yog ib qho tshuaj tua kab mob, tiv thaiv kab mob thiab glutamate. antagonist. Minocycline hydrochloride muaj anticancer, tiv thaiv inflammatory thiab glutamate antagonistic teebmeem. Minocycline hydrochloride txo glutamate neurotransmission thiab qhia txog cov khoom tiv thaiv neuroprotective thiab antidepressant teebmeem. Minocycline hydrochloride inhibits cov kab mob protein synthesis los ntawm kev khi rau 30S subunit ntawm cov kab mob ribosome, ua rau cov teebmeem bacteriostatic.

Txoj kev tsim khoom

Ib txoj hauv kev rau kev npaj ntawm minocycline hydrochloride, suav nrog cov kauj ruam hauv qab no: 1) Kev npaj ntawm sanguinarine: A. Kev npaj ntawm 7-dechlorohydrochloric acid desmethyl aureomycin: 7-dechlorohydrochloric acid desmethyl aureomycin tau yaj hauv ethanol, triethylamine thiab palladium carbon tau ntxiv, thiab cov tshuaj tiv thaiv tau ua nyob rau hauv cov xwm txheej ntawm hydrogen raws li kev tiv thaiv roj, thiab cov tshuaj tiv thaiv tau lim kom tau lub ncuav mog qab zib lim, thiab tom qab ntawd lub ncuav mog qab zib tau ntxuav nrog ethanol, thiab qhuav kom tau txais {{3} } dechlorohydrochloric acid desmethyl aureomycin; B, Kev npaj ntawm santonin: 7-dechlorohydrochloric acid desmethyl chlortetracycline, methanol, p-toluenesulfonic acid tau tov thiab yaj ntawm -5 degree, rhodium carbon tau ntxiv, thiab cov tshuaj tiv thaiv tau nqa tawm nyob rau hauv cov xwm txheej ntawm hydrogen Raws li kev tiv thaiv roj, thiab cov tshuaj tiv thaiv tau txo qis rau 5 degree, thiab triethylamine tau ntxiv rau cov slurry kom yaj, thiab cov tshuaj tiv thaiv tau lim thiab ntxuav nrog methanol, cov lim tau sau, thiab pH ntawm cov lim tau hloov kho. mus rau 1. Tom qab ntawd, lub ncuav mog qab zib lim tau ntxuav nrog methanol thiab qhuav kom tau santol; 2) kev npaj ntawm 7-iodosantoin: noj 5 wt. ib feem ntawm muaj zog acid sulfuric acid, 1 wt. ib feem ntawm santol, 1 wt. Ib feem ntawm N-iodosuccinimide, yaj cov santol hauv cov kua qaub uas muaj zog ntawm 10 degree, thiab tom qab ntawd cov tshuaj tiv thaiv tau txav mus rau qhov chaw qis qis ntawm 0 degree, ntxiv N-iodosuccinimide, thiab cov tshuaj tiv thaiv yog stirred rau 2 h. Qhov kawg taw tes ntawm cov tshuaj tiv thaiv ntawm cov kauj ruam 2) yog raws li nram no: cov tshuaj tiv thaiv kua yog ntsuas los ntawm HPLC, thiab cov tshuaj tiv thaiv tau pom nyob rau hauv ib tug tsawg kub ib puag ncig ntawm -5 degree . HPLC kuaj pom cov tshuaj tiv thaiv, thaum cov ntsiab lus ntawm cyclamen tsawg dua 3% kom xaus cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv tau txais nyob rau hauv kauj ruam 2) yog tov nrog 10 wt. ib feem ntawm cov dej los kho qhov sib tov, thiab qhov sib tov tau ntws los ntawm kab sib cais nruab nrog 20 wt. ib feem ntawm macroporous adsorbent resin nyob rau hauv 1 teev, thiab ces eluted nrog 30 wt. Ib feem ntawm 35% aqueous methanol tov, thiab ces eluted nrog 20 wt. ib feem ntawm 60% aqueous methanol tov, thiab eluent uas muaj lub hom phiaj tivthaiv tau sau; cov eluent tau concentrated nyob rau hauv txo siab ntawm 40 degree, thiab cov precipitated Cov khoom yog lim thiab qhuav nyob rau hauv txo siab ntawm 30 degree rau 5 teev kom tau txais 7-iodosaniline; 3) Kev npaj ntawm minocycline hydrochloride: 1 wt. ntawm 7-iodosaniline, 10 wt. N, N-dimethylformamide, 0.01 wt. ntawm bis (triphenylphosphine) dichloropalladium tau yaj nrog nplawm ntawm 50 degree, thiab tom qab ntawd 0.3 wt. ntawm dimethylamino-trimethylstannane thiab 0.5 wt. ntawm triethylamine tau ntxiv. Cov tshuaj tiv thaiv tau nplawm rau 6 teev. Qhov kawg taw tes ntawm cov tshuaj tiv thaiv hauv qib 3) yog tias cov tshuaj tiv thaiv tau kuaj pom los ntawm HPLC, thiab cov tshuaj tiv thaiv tau xaus thaum cov ntsiab lus ntawm 7-iodosanillin tsawg dua 2%. Cov tshuaj tiv thaiv tau txais nyob rau hauv kauj ruam 3) tau ntws los ntawm ib kab sib cais nruab nrog 20 wt. feem ntawm macroporous adsorbent resin nyob rau hauv 2 teev, thiab ces eluted sequentially nrog 20 wt. dej, 40 wt. ib feem ntawm 20% aqueous methanol tov, thiab 10 wt. Ib feem ntawm 80% methanol tov, thiab cov eluate uas muaj lub hom phiaj tivthaiv tau sau, thiab cov eluate tau concentrated nyob rau hauv lub siab txo thiab tom qab ntawd kho pH ntawm cov tshuaj tiv thaiv rau 1.0 nrog concentrated hydrochloric acid, thaum cov tshuaj tiv thaiv yog ces decolored nrog activated. carbon. Tom qab ntawd, pH ntawm cov tshuaj tiv thaiv tau hloov mus rau 3.8 nrog ammonia, khov crystallization tau ua, thiab lub ncuav mog qab zib lim tau qhuav tom qab pom kom tau minocycline hydrochloride.

Khoom siv

Clinically, nws yog tsuas yog siv rau kev ua pa, urinary, daim tawv nqaij thiab cov ntaub so ntswg mos kab mob tshwm sim los ntawm cov tshuaj tiv thaiv kab mob, raws li zoo raws li meningitis thiab nws cov cab kuj, mob osteomyelitis, cholecystitis, gonorrhea thiab hais txog.

Minocycline hydrochloride