Menatetrenone

1.Product lub npe: Menatetrenone
2.Appearance: daj hmoov
3.Molecular Formula: C31H40O2
4.Molecular Luj: 444.65
5. CAS Nr.: 863-61-6
6.Purity: 99%
7.Test Method: HPLC
8.Kev Them Nyiaj: TT, Western Union, Paypal, Pingpong, Xtransfer, ect.
9.Shelf Life: 2 xyoos

Xa kev nug Tsham tam sim no

Hauj lwm lawm

Khoom Taw Qhia

Menatetrenone yog cov khoom siv daj daj uas tau los ntawm acetone-ethanol lossis methanol-chloroform, molecular hnyav 580.90, melting point 51-52 degree, insoluble hauv dej, me ntsis soluble hauv roj, soluble hauv ethanol, ether, acetone, benzene, chloroform thiab lwm yam. organic solvents, tab sis nws solubility yog me ntsis tsis zoo dua li vitamin K1. Decomposed los ntawm muaj zog acid, oxidant, alkali thiab lub teeb. Cov qauv qauv ntawm tetraenylmenaquinone yog: Tau qhov twg los Tetraenylmenaquinone (Vitamin K2) yog dav pom nyob rau hauv nplooj ntsuab thiab zaub, tab sis kuj nyob rau hauv cov ntses, nqaij, cheese thiab daim siab roj. Nws tuaj yeem muab rho tawm los ntawm cov pob kws nplooj thiab cov ntses lwj, lossis ua los ntawm 2-methylnaphthoquinone-1,4.
Vitamin K yog ib chav kawm ntawm cov tebchaw nrog cov qauv quinone, uas suav nrog tsib chav kawm ntawm cov khoom sib txuas nrog cov qauv sib txawv, piv txwv li, vitamin K1, K2, K3, K4, thiab K5.Vitamin K2 yog cov khoom sib txuas hauv cov xim daj daj daj ua ke feem ntau los ntawm cov kab mob hauv plab, uas muaj tag nrho ntawm 14 nyob ntawm qhov ntev ntawm isoprenoid side-chain ntawm C3, thiab ib qho siv rau kev kho mob pob txha yog vitamin K2 (20), piv txwv li, tetracene Tetraenylmenaquinone. Cov kev tshawb fawb tau pom tias tetrenone muaj cov teebmeem osteogenic, txhawb cov calcium metabolism, tab sis kuj inhibit pob txha resorption los ntawm osteoclasts, yog li ua rau pob txha ceev thiab tiv thaiv osteoporosis. Tetranaphthoquinone yog ib yam khoom oily thiab yog yooj yim decomposed nyob rau hauv lub xub ntiag ntawm lub teeb, yog li nws yog haum rau mos capsule ntau npaum daim ntawv.

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Menatetrenone

Physiological teebmeem
Tetraenylmenaquinone, tseem hu ua vitamin K2, yog ib txwm muaj cov vitamin uas muaj cov qauv ntawm menaquinone thiab muaj cov nyhuv los tiv thaiv haemorrhagic. Xyoo 1929, Daim tau tshawb pom tias muaj ob hom vitamin K hauv qhov xwm txheej, K1 thiab K2, ob qho tib si yog naphthoquinones. Tetraenaphthoquinone yog daj crystalline hmoov los yog oily kua, insoluble nyob rau hauv dej, yooj yim soluble nyob rau hauv organic solvents thiab zaub roj, tshav kub-resistant, tab sis yooj yim puas los ntawm lub teeb. Nws tuaj yeem txhawb kev tsim cov hepatic synthesis ntawm plasminogen thiab tswj cov synthesis ntawm coagulation yam VII, IX thiab X, yog li ua kom cov ntshav coagulation. Tsis tas li ntawd, nws plays lub luag haujlwm tseem ceeb hauv qabzib phosphorylation hauv cov hlwb. Hauv qee cov kab mob (xws li Mycobacterium), nws tuaj yeem siv los ua ib feem ntawm cov kab mob ua pa. Nyob rau hauv qhov tsis muaj peev xwm, lub sij hawm txhaws yog ntev, yog li thaum muaj kev raug mob, nws los ntshav. Cov kab mob hauv plab hnyuv ntawm tib neeg thiab tsiaj txhu tuaj yeem ua rau nws, yog li nws feem ntau tsis yooj yim kom tsis muaj peev xwm.

Mechanism ntawm kev ua
Tetraenylmenaquinone (vitamin K2) muaj cov txheej txheem ntawm kev ua haujlwm zoo ib yam li cov vitamin K1, thiab muaj peev xwm pab cov enzyme gamma-glutamyl carboxylase hloov glutamate (Glu) rau gamma-carboxyglutamate (Gla). Cov txheej txheem no muaj txiaj ntsig zoo hauv kev tsim cov Gla-proteins (cov protein uas muaj Gla), piv txwv ntawm cov hauv qab no: osteocalcin: pob txha mineralization GAS6: cell proliferation thrombin, anticoagulant proteins: ntshav homeostasis.

Kev mob tshwm sim
Qee zaum mob plab, xeev siab, ntuav, raws plab, mob plab, plab zom mov. Qee zaum ua pob, liab ntawm daim tawv nqaij, khaus, mob taub hau. Tej zaum yuav muaj GOT, GPT, -GTP, BUN, thiab lwm yam.

Tsis muaj peev xwm
Tib neeg cov kab mob hauv plab tuaj yeem tsim tetraenylmenaquinone (vitamin K2), yog li feem ntau tsis muaj kev pheej hmoo ntawm kev tsis txaus. Txawm li cas los xij, yog tias siv cov tshuaj sulfa mus ntev lossis tshuaj tua kab mob los tiv thaiv cov kab mob, lossis ib qho ua rau lipid malabsorption: xws li cov kab mob hauv cov hlab ntsha, cov quav muaj roj, mob plab, mob plab, mob pancreatic, thiab lwm yam, yuav ua rau cov vitamin K tsis txaus. Kev raug mob me me, ib txwm tsis muaj mob tuaj yeem ua rau los ntshav tuag hauv cov tsiaj tsis muaj K. Yog li ntawd, cov neeg mob uas muaj cov kab mob plab hnyuv thiab cov kab mob hauv lub cev yuav tsum tau txhaj tshuaj vitamin K ua ntej kev phais. Cov menyuam mos yug tshiab uas muaj menyuam tsis taus plab hnyuv lumen kuj tuaj yeem muaj K deficiency neonatal haemorrhage, uas tuaj yeem txuas ntxiv mus txog thaum lub plab hnyuv lumen muaj cov kab mob. Qhov no tuaj yeem tiv thaiv tau los ntawm kev txhaj tshuaj ua ntej yug menyuam ntawm K rau hauv tus poj niam cev xeeb tub. Yog tias txhaj ncaj qha rau tus menyuam mos, nws yuav tsum tsis txhob muab ntau dhau ib zaug, thiaj li tsis ua rau hyperbilirubinemia thiab jaundice. Cov neeg laus tsis muaj kev pheej hmoo ntawm cov vitamin K tsis txaus yog tias cov rog zoo absorbed hauv cov hnyuv. Nws yog qhov paub zoo tias cov neeg mob uas tsis muaj vitamin K tau txo cov thromboplastin hauv cov ntshav thiab lub sijhawm ua rau lub sijhawm ntev. Yog li ntawd, nws ntseeg tau tias lub luag haujlwm tseem ceeb ntawm K yog los txhawb kev sib txuas ntawm plasminogen hauv daim siab. Tom qab ntau xyoo ntawm kev tshawb fawb, nws tau pom tias vitamin K kuj txhawb kev tsim cov coagulation yam VII, IX, X, thiab lwm yam hauv daim siab. Thaum tsis muaj K, cov ntshav ntawm cov coagulation yam yuav poob. Vim li no, thaum muaj mob qog noj ntshav lossis mob cirrhosis, daim siab cov ntaub so ntswg raug mob hnyav thiab lub siab ua haujlwm tsis zoo, txawm tias muab cov vitamin K los, nws tseem ua tsis tau zoo.

Khoom siv

Ua kom cov pob txha loj hauv cov neeg mob osteoporosis.

Menatetrenone