Statin lipid-txo cov tshuaj
Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, tsis tsuas yog txo qis tag nrho cov cholesterol (TC) thiab cov lipoprotein tsawg (LDL), tab sis kuj tuaj yeem txo triacylglycerol (TG). ) rau qee qhov, thiab tuaj yeem nce siab lipoprotein (HDL), yog li statins tuaj yeem hu ua ntau cov tshuaj lipid-txo qis.
Cov txheej txheem ntawm kev txiav txim ntawm statins yog kom muaj kev sib tw inhibit endogenous cholesterol synthesis tus nqi-txheej enzyme HMG-CoA reductase, thaiv cov intracellular xyvalonate metabolic txoj kev, txo intracellular cholesterol synthesis, thiab tawm tswv yim txhawb cov qib qis ntawm cell membrane nto. Qhov nce ntawm tus lej thiab kev ua haujlwm ntawm qhov ntom ntom lipoprotein (LDL) receptors ua rau kom cov roj cholesterol tshem tawm thiab txo qis. Clinically, nws yog siv los txo cov roj cholesterol, tshwj xeeb tshaj yog cov lipoprotein-cholesterol tsawg (LDL-C), thiab kho atherosclerosis. Ua cov tshuaj zoo tshaj plaws rau kev tiv thaiv kab mob plawv thiab kho.
Lovastatin thiab simvastatin: Lovastatin yog thawj statin uas yuav tsum tau ua lag luam, thiab simvastatin yog tus thib ob statin los ua lag luam. Nws yog raws li lovastatin thiab muaj cov qauv me me. hloov. Cov khoom ntawm ob qhov zoo sib xws, lipid-txo qis siv yog nruab nrab, thiab simvastatin feem ntau siv.
Ob leeg yog metabolized los ntawm lub siab tshuaj enzyme CYP3A4, thiab ntau yam tshuaj yog metabolized los ntawm tib txoj kev, yog li muaj ntau yam kev sib cuam tshuam nrog lwm yam tshuaj, thiab yuav tsum tau them nyiaj mloog thaum muab tshuaj. Ob leeg ntawm lawv muaj lub sijhawm luv luv ntawm kev ua haujlwm thiab yuav tsum tau ua ua ntej mus pw kom ua kom cov lipid-txo qis.
Pravastatin: Nws yog ib qho nruab nrab-ua yeeb yam statin, uas tsis yog metabolized los ntawm daim siab tshuaj enzymes, thiab muaj kev cuam tshuam nrog lwm yam tshuaj, tsis tshua muaj tshwm sim, tsis tshua muaj kev cuam tshuam rau cov ntshav qab zib, luv luv ua yeeb yam, thiab yuav tsum tau noj ua ntej mus pw. .
Fluvastatin: Nws yog cov tshuaj statin nruab nrab, feem ntau metabolized los ntawm lub siab tshuaj enzyme CYP2C9, thiab cuam tshuam nrog qee cov tshuaj. Nws yog luv-acting thiab yuav tsum tau noj ua ntej mus pw. Nws yog siv tsawg dua tam sim no.
Atorvastatin: Nws yog ib qho muaj zog statin uas muaj cov nyhuv ntev thiab tuaj yeem noj ntawm lub sijhawm teem tseg txhua hnub. Nws yog feem ntau metabolized los ntawm lub siab tshuaj enzyme CYP3A4, thiab nws muaj ntau yam kev sib tshuam nrog lwm yam tshuaj.
Rosuvastatin: Nws yog ib qho muaj zog statin thiab muaj cov nyhuv ntev. Nws tuaj yeem noj ntawm lub sijhawm teem tseg txhua hnub. Nws yog tsuas yog tawm los ntawm cov quav, ib feem ntawm lub raum, thiab ib feem me me yog metabolized los ntawm daim siab. Nws muaj qee qhov kev cuam tshuam nrog lwm cov tshuaj, thiab nws muaj kev nyab xeeb siab thaum siv ua ke.
Pitavastatin: Nws yog cov tshuaj statin nruab nrab thiab muaj cov nyhuv ntev. Nws tuaj yeem noj ntawm lub sijhawm teem tseg txhua hnub. Noj cov tshuaj tsawg tshaj plaws ntawm statins, uas feem ntau yog tawm hauv cov quav, muaj kev cuam tshuam nrog lwm cov tshuaj, muaj kev phiv tsawg, thiab muaj kev cuam tshuam tsawg tshaj plaws ntawm cov ntshav qab zib.
Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias statins muaj ntau yam tsis-lipid-txo cov teebmeem, nrog rau inhibiting atherosclerosis thiab thrombosis, relieving rejection tom qab hloov lub cev, kho osteoporosis, anti-tumor, thiab anti-senile dementia. thiab ntau lwm yam haujlwm.
