Daim Ntawv Thov Ntawm Microcrystalline Cellulose hauv Pharmaceutical
Microcrystalline cellulose (MCC), lub ntsiab tivthaiv yog linear polysaccharide khi los ntawm -1, 4-glucosidic bonds, yog ib tug dawb-flowing natural cellulose hydrolyzed mus rau qhov txwv degree ntawm polymerization (LODP) los ntawm dilute acid. Zoo heev luv luv pas nrig-zoo li los yog hmoov zoo li ntxeem tau hais, muaj li ntawm dawb, tsw tsw, saj tsis muaj crystalline hmoov.
Hauv cov nroj tsuag fibers, microcrystalline cellulose suav txog li 70 feem pua, thiab lwm yam 30 feem pua yog amorphous. Raws li kev pom ntawm cov qauv tshwj xeeb thiab cov khoom ntawm microcrystalline cellulose, nws yog dav siv los ua ib qho disintegrant, ruaj khov emulsifier, thiab lwm yam hauv lub teb chaws kev lag luam xws li tshuaj thiab kev noj qab haus huv, zaub mov thiab dej haus, thiab kev lag luam tshuaj lom neeg.
Vim tias cellulose muaj nyob rau hauv cov xwm txheej, ntau pua lab tons ntawm cellulose-nplua nuj biomass residues tuaj yeem tsim txhua xyoo hauv ntiaj teb. Yog tias cov khoom seem no tau hloov pauv thiab siv tau zoo, lawv yuav yog cov peev txheej nplua nuj. Hauv Suav teb, kev nthuav dav ntawm cov khoom lag luam tanning, tshuaj txhua hnub, tshuaj, zaub mov, thiab chlor-alkali kev lag luam thiab kev txhim kho cov khoom lag luam tau nce qhov kev thov rau microcrystalline cellulose txhua xyoo, yog li microcrystalline cellulose muaj kev lag luam dav dav. Thoob ntiaj teb, microcrystalline cellulose tau suav nrog hauv US FDA Kev Ntsuas Cov Khoom Noj Ntxiv Kev Nyab Xeeb Kev Nyab Xeeb (GRAS), pom zoo raws li cov khoom noj ntxiv hauv Tebchaws Europe, thiab suav nrog FDA's "Inactive Ingredients Guide", thiab tau pom zoo hauv tebchaws United Kingdom rau kev txhaj tshuaj tsis tau. kev npaj.
Microcrystalline cellulose feem ntau yog siv los ua adsorbent, suspending agent, diluent, disintegrant. Microcrystalline cellulose yog dav siv nyob rau hauv kev npaj tshuaj, feem ntau yog siv raws li diluent thiab binder nyob rau hauv lub qhov ncauj ntsiav tshuaj thiab tsiav tshuaj, tsis tsuas yog rau ntub granulation tab sis kuj rau qhuav ncaj qha compression. Kuj tseem muaj qee qhov lubrication thiab disintegration, uas yog qhov tseem ceeb heev hauv kev npaj cov ntsiav tshuaj.
Vim muaj cov hydrogen bonds ntawm cov molecules ntawm microcrystalline cellulose, cov hydrogen bonds yog txuam thaum nias, yog li nws muaj ib tug high degree ntawm compressibility thiab feem ntau yog siv raws li ib tug binder; Tom qab cov ntsiav tshuaj compressed ntsib cov kua, cov dej noo sai sai nkag mus rau microcrystalline cellulose uas muaj microcrystalline cellulose. Nyob rau hauv cov ntsiav tshuaj ntawm crystalline cellulose, hydrogen daim ntawv cog lus yog tawg tam sim ntawd, yog li nws yuav siv tau raws li ib tug disintegrant. Yog li ntawd, nws yog ib tug dav siv excipient nyob rau hauv cov ntsiav tshuaj ntau lawm, uas yuav txhim khu lub hardness ntawm cov ntsiav tshuaj. Piv txwv li, nyob rau hauv kev npaj ntawm rifampicin ntsiav tshuaj, microcrystalline cellulose thiab starch (mass ratio ntawm 6.25: 1) thiab ntau yam raw cov ntaub ntawv yuav muab sib xyaw uniformly thiab ncaj qha compressed, thiab cov khoom disintegrates mus rau hauv ib tug pos huab nyob rau hauv 1 feeb. Ntxiv mus, cov ntsiab lus tseem tsis hloov pauv nyob rau lub sijhawm siv tau, thiab cov tshuaj ruaj khov tuaj yeem txhim kho tau zoo. Lwm qhov piv txwv, vim qhov sib ntxiv ntawm microcrystalline cellulose, qhov kev sib cais ntawm prednisone acetate thiab berberine acetate (berberine hydrochloride) ntsiav tshuaj tau nce mus rau ntau dua 80 feem pua. Tsis tas yuav mus dhau cov txheej txheem granulation ib txwm siv thaum siv microcrystalline cellulose ua cov khoom pabcuam rau cov ntsiav tshuaj. Piv txwv li, nyob rau hauv kev npaj ntawm Kebiqing ntsiav tshuaj, microcrystalline cellulose yog ntxiv, uas daws qhov mob hnyav tshwm sim los ntawm qhov yooj yim noo noo nqus ntawm Kebiqing ntub granulation ntsiav tshuaj. maj phenomenon, thiab disintegrate sai heev.
Microcrystalline cellulose kuj tseem siv tau los ua tus neeg sawv cev tso tawm rau cov kws tshuaj. Cov txheej txheem tso tawm tsis tu ncua yog nkag mus ntawm cov tshuaj nquag mus rau hauv cov qauv ntxeem tau ntawm cov cab kuj. Cov khoom siv nquag yog muaj los ntawm cov ntawv cog lus hydrogen intermolecular, thiab cov khoom siv tau ruaj khov tom qab ziab. Thaum cov tshuaj nquag tso tawm, vim qhov o tshwm sim los ntawm qhov sib txawv ntawm cov dej hauv capillary system ntawm cov cab kuj polymer, kev sib raug zoo ntawm cov cab kuj los ntawm lub hauv paus thiab cov khoom siv ruaj khov raug rhuav tshem, thiab cov khoom siv maj mam tso tawm.
Microcrystalline cellulose hmoov tuaj yeem tsim kom muaj qhov ruaj khov dispersion hauv dej, thiab nws tuaj yeem sib xyaw nrog cov tshuaj los ua cov tshuaj nplaum los yog tshem tawm cov tshuaj ua kua, thiab tuaj yeem siv ua tshuaj ntsiav. Microcrystalline cellulose yog gelatinized los ntawm lub zog nplawm hauv dej, thiab tseem tuaj yeem siv los tsim cov tshuaj txhuam thiab tshem tawm hom tshuaj npaj.
