Dab tsi yog qhov cuam tshuam ntawm Indapamide?

Cov kev phiv ntawm indapamide yog dab tsi?

Indapamide, ib qho tshuaj txo cov ntshav hauv qhov ncauj, kuj yog ib qho tshuaj tiv thaiv kab mob potassium. Vim hais tias cov tshuaj no yog cov tshuaj uas tsis yog-thiazide sulfa, nws yuav tsum tsis txhob siv rau cov neeg mob uas nkag siab zoo rau sulfa.

Antihypertensive mechanism ntawm indapamide

Pib antihypertensive mechanism: lub ntsiab sodium diuresis kom txo qhov ntim ntawm cov ntshav thiab cov kua dej ntxiv.

Lub sij hawm ntev antihypertensive mechanism: Vim nws cov sodium tso tawm cov nyhuv, nws txo cov concentration ntawm Na ntxiv nyob rau hauv vascular du leeg hlwb, thiab los ntawm Na plus -Ca2 ntxiv pauv, nws txo cov intracellular Ca2 ntxiv, txo cov reactivity ntawm vascular du nqaij mus vasoconstrictor tshuaj, thiab txhim kho qhov rhiab heev rau vasodilatory tshuaj.

Thiazide diuretics yog tshwj xeeb tshaj yog haum rau cov neeg laus uas muaj ntshav siab, yooj yim systolic ntshav siab los yog lub plawv tsis ua hauj lwm.

Thiazide diuretics thiab ACEI / ARB muaj kev sib koom ua ke los tiv thaiv kev mob ntshav siab:

Kev siv ntev ntev ntawm thiazide diuretics tuaj yeem ua rau nce kev ua haujlwm ntawm renin thiab angiotensin ⅱ qib. ACEI / ARB tuaj yeem thaiv cov synthesis ntawm angiotensin ⅱ thiab inhibit qhov kev sib txuas ntawm angiotensin ⅱ rau nws cov receptor, thiab ua kom muaj kev sib koom ua ke ntawm cov nyhuv antihypertensive nrog thiazide diuretics.

Kev mob tshwm sim

Cov kev mob tshwm sim muaj xws li:

Hypokalemia (ua tib zoo saib xyuas qhov poob ntawm cov poov tshuaj ions tom qab tso zis thiab kiv taub hau);

Nquag;

Postural hypotension ( kiv taub hau tom qab zaum los yog squatting).