Synthesis Method Thiab Siv Chlorzoxazone

Clozoxazoneyog lub qhov ncauj zoo hauv nruab nrab cov leeg pob txha relaxant nrog cov tshuaj sib txawv kiag li los ntawm tag nrho lwm cov leeg nqaij. Nws tsuas yog ua rau ntawm tus txha caj qaum thiab subcortical chaw ntawm lub hlwb, inhibiting multi-synaptic reflex txuam nrog cov leeg nqaij spasms, ua rau cov leeg so, txo qhov mob los ntawm spasms, thiab ua kom yooj yim ntawm cov leeg nqaij. Acetaminophen yog ib yam tshuaj uas tsis yog steroidal antipyretic thiab analgesic tshuaj uas tej zaum yuav muaj analgesic thiab antipyretic los ntawm inhibiting lub synthesis ntawm prostaglandins. Cov kev tshawb fawb ntawm cov leeg nqaij relaxant nyhuv ntawm txoj kev nce toj hauv cov nas tau pom tias cov tshuaj chlorzoxazone nthuav tawm cov tshuaj tseem ceeb ntawm cov leeg nqaij so thiab muaj kev tiv thaiv zoo ntawm strychnine induced qaug dab peg hauv cov nas. Lub xub ntiag ntawm paracetamol hauv cov ntsiav tshuaj chlorzoxazone tuaj yeem txhim kho cov nyhuv ntawm chlorzoxazone. Cov phaj kub analgesic kuaj tau pom tias cov tshuaj chlorzoxazone muaj cov nyhuv analgesic tseem ceeb nyob rau hauv cov koob tshuaj, thiab tseem muaj qhov cuam tshuam loj heev rau qhov mob writhing cov tshuaj tiv thaiv tshwm sim los ntawm potassium antimony tartrate hauv cov nas, qhia txog kev sib raug zoo ntawm koob tshuaj. Cov txiaj ntsig kev sim tau pom tias acetaminophen thiab chlorzoxazone muaj cov nyhuv analgesic synergistic.

Synthesis txoj kev ntawmtshuaj chlorzoxazone:
Siv 2,5-dichloronitrobenzene ua raw khoom, 2-amino-4-chlorophenol tau txais los ntawm hydrolysis thiab txo cov tshuaj tiv thaiv, ua raws li cyclization hauv hydrochloric acid kom tau chlorzoxazone hauv tag nrho cov txiaj ntsig ntawm 84 feem pua.

1. Cov tshuaj tiv thaiv ntawm pyrimidinyl imidazolyl ethanol (MAIE) nrog 2-chloro-3-acetylaminopropionic acid nyob rau hauv alkaline tej yam kev mob yields 2 - (2-pyrimidinyl imidazol-1-yl) { {6}}acetylaminopropionic acid (MAIMP).
2. Cov tshuaj tiv thaiv MAIMP nrog sodium nitrite los yog ammonium nitrite los tsim ib qho kev sib xyaw ua ntej ntawm chlorzoxazone.
3. chlorzoxazone tau txais los ntawm kev txo cov tshuaj tiv thaiv.

Kev siv ntawmtshuaj chlorzoxazone:
Chlorzoxazonentsiav tshuaj yog ib hom tshuaj analgesic thiab anti-inflammatory tshuaj. Nws cov khoom tseem ceeb yog chlorzoxazone, uas yog cov leeg pob txha relaxant. Nws tsuas yog ua rau ntawm tus txha caj qaum thiab cov chaw subcortical ntawm lub hlwb kom inhibit ntau cov txheej txheem reflex cuam tshuam nrog cov leeg nqaij, yog li so cov leeg, txo qhov mob, thiab ua kom yooj yim ntawm cov leeg nqaij.
Clozoxazoneyog cov tshuaj tua kab mob dav dav uas siv tau los kho cov kab mob tiv thaiv kab mob, tshwj xeeb tshaj yog cov tshuaj tiv thaiv kab mob Staphylococcus aureus, C kis kab mob, mob ntsws, raws plab thiab lwm yam kab mob sib kis.
Tsis tas li ntawd, chlorzoxazone tuaj yeem siv rau kev kho mob thiab tiv thaiv kab mob hauv plab.

Peb tuaj yeem muab cov ntaub ntawv API feem ntau rau cov neeg siv khoom, Yog tias koj muaj lus nug lossis xav paub ntxiv, thov hu rau peb ntawm E-mail:info@haozbio.com