Pharmacological teebmeem ntawm Clobetasol
Daim ntawv noj tshuaj
1. 0.05 feem pua ml.
2. Nyhav: 25g.
3. Yog': 25 g.
4. Tshuaj pleev: 5g, 10g (muaj 0.02 feem pua ntawm tag nrho cov khoom thiab 2 feem pua lauryl ketone thiab matrix).
Pharmacological Action
Clobetasol yog ib qho muaj zog hauv zos corticosteroid. Kev siv sab nraud yog yooj yim nqus los ntawm daim tawv nqaij, yog li kev kho mob luv luv rau cov tawv nqaij tawv nqaij yog qhov tshwj xeeb. Nws muaj zog capillary constriction nyhuv, thiab nws anti-inflammatory nyhuv yog 112.5 npaug ntawm hydrocortisone. Thiab anhydrous sodium retention, muaj qee lub luag haujlwm hauv kev txhawb nqa tawm ntawm sodium thiab potassium. Hauv zos daim ntawv thov clobetasol kuj inhibits DNA synthesis thiab mitosis ntawm epidermal hlwb, uas yog lwm lub mechanism ntawm clobetasol cov kev kho mob nyhuv ntawm daim tawv nqaij kab mob uas yus muaj los ntawm cell renewal thiab proliferation, xws li psoriasis. Thiab nws muaj cov tshuaj tiv thaiv khaus thiab vasoconstrictive, uas tuaj yeem txo qis kev cuam tshuam thiab kev mob tshwm sim.
Pharmacokinetics
Kwv yees li 1 feem pua ntawm cov ntawv thov hauv zos ntawm clobetasol muaj kev kho mob los ntawm daim tawv nqaij. Yog tias qhov chaw thov yog npog nrog zaj duab xis yas, 10 feem pua ntawm cov tshuaj tuaj yeem dhau ntawm daim tawv nqaij. Thaum qhov chaw siv loj, qhov concentration siab, lossis muaj qhov mob ntawm daim tawv nqaij, qhov nqus ntawm clobetasol tuaj yeem nce ntxiv. Hauv cov neeg mob uas muaj lub siab ua haujlwm tsis zoo, lub sijhawm nyob ntawm cov tshuaj hauv lub cev yog sib txuas nrog ntev.
Cov lus qhia
Siv rau psoriasis, tawv tawv eczema, lichen planus, discoid lupus erythematosus, thiab lwm yam. Thaum qhov kev ua tau zoo ntawm lwm cov tshuaj hormones tsis zoo, clobetasol tuaj yeem siv. Nws yog tsim nrog kev nkag mus rau cov tawv nqaij ua rau muaj kev sib cav, cov kab mob sab nraud, cov tshuaj tiv thaiv kab mob sab nraud, qhov quav sab nraud, thiab qhov tsis zoo thiab qhov chaw mos thiab qhov tsis zoo thiab qhov tsis zoo thiab qhov quav thiab lwm yam.
Contraindications
1. Nws yog txwv tsis pub rau cov neeg uas tsis haum rau clobetasol.
2. Thaum ntxov ntawm daim tawv nqaij kis kab mob.
3. daim tawv nqaij ulcerative lesions.
4. Pob txuv vulgaris thiab rosacea.
5. Perioral dermatitis.
6. Cov me nyuam.
