Roflumilast hmoov

Hauj lwm lawm

Whntawm's Roflumilasthmoov ?

Roflumilast,ib qho phosphodiesterase-4 (PDE-4) inhibitor, yog tshuaj kho tshiab rau COPD. Nws yog siv los kho cov tsos mob ntawm bronchitis ntsig txog hnoos thiab hnoos qeev hyperplasia hauv cov neeg mob uas muaj COPD hnyav.

Nws yog thawj cov tshuaj hauv kev kho mob tshiab rau COPD hnyav. Nws kuj yog thawj cov tshuaj tiv thaiv qhov ncauj tshwj xeeb tsim rau cov neeg mob COPD. Nws cov khoom tshwj xeeb txhawb kev tswj hwm cov neeg mob COPD zoo dua: Thaum siv nrog cov tshuaj bronchodilators hauv cov neeg mob uas muaj mob hnyav tshaj plaws ntawm cov kab mob ntsws ntsws, rofluast muab cov txiaj ntsig ntxiv ntawm kev txo cov tsos mob thiab tus nqi ntawm cov kab mob, yog li, nws tau los ua tus thawj cov tshuaj rau lub hom phiaj tshwj xeeb phenotype ntawm COPD, uas yog, cov neeg mob uas muaj kev txwv tsis pub muaj huab cua hnyav cuam tshuam nrog hnoos ntev thiab hypersputum, thiab keeb kwm ntawm cov kab mob rov tshwm sim dua.

Synonym

ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B9302-107; BY217; BYK20869; Daxas; Roflumilast/3-(cyclopropChemicalbookylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)- N-(3,{21}}dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

PKhoom Specification

Ftsis ua haujlwm

Roflumilastyog siv los ntawm qhov ncauj thiab metabolized rau hauv N-oxide los ntawm cytochrome oxidase P450 (CYP) 3A4 thiab CYP1A2 enzymes tom qab nkag mus rau hauv lub cev. Qhov kev ua ntawm roflast N-oxide tsuas yog 2-3 lub sij hawm tsis muaj zog tshaj li ntawm roflast, tab sis kuj muaj ntau dua PDE -4 selectivity. Kwv yees li 90 feem pua ​​​​ntawm PDE-4 inhibitory nyhuv hauv tib neeg yog tsim los ntawm roflast N-oxide, thiab lwm 10 feem pua ​​yog tsim los ntawm roflast qauv. Lub plasma dawb concentration ntawm roflurast n-oxide yog li ntawm 1 ~ 2nmoChemicalbookl·l-1 tom qab 24 teev ntawm qhov ncauj kev tswj hwm ntawm roflurast 500ug ib hnub ib zaug hauv cov neeg noj qab haus huv, thiab cov ntshav plasma protein binding muaj peev xwm ntawm roflurast n-oxide yog li 97 feem pua. . Kev haus luam yeeb tsis tshua muaj txiaj ntsig rau cov tshuaj pharmacokinetics ntawm rofluast. Roflast feem ntau yog qhia nyob rau hauv inflammatory cells txuam nrog mob hawb pob, nrog rau eosinophils, neutrophils, thiab mast hlwb. Cov tshuaj no tuaj yeem ua haujlwm tshwj xeeb rau qee cov enzymes koom nrog hauv cov leeg nqaij leeg, tiv thaiv cAMP degradation, yog li thaiv cov teeb liab proinflammatory, thiab muaj kev tiv thaiv kab mob. Nws tau txais txiaj ntsig zoo curative hauv kev kho mob hawb pob thiab mob ntsws obstructive pulmonary. Roflast kuj tseem cuam tshuam qhov tsis zoo ntawm cov tsos mob ua pa thiab txhim kho lub neej zoo ntawm cov neeg mob.

Daim ntawv thov

Nws yog siv rau kev tiv thaiv thiab kho cov kab mob ua pa ntawm cov tsiaj nyeg thiab nqaij qaib, thiab kev kho mob ntawm cov kab mob ntsws ntev ntev (COPD) thiab mob ntsws ntsws nrog hnoos hnoos ntau dhau, mob hawb pob, mob hawb pob, mob ntsws asthma, mob ntsws thiab mob ntsws ntev nrog kev ua pa txawv txav. kab mob, mob plab, thiab lwm yam.

Ntim & Xa

Feem ntau cov ntim yog 25kg / nruas; tshaj 50kg peb tuaj yeem nkoj los ntawm huab cua; tshaj 100kg peb tuaj yeem nkoj los ntawm hiav txwv.

FAQ

1. Kuv puas tuaj yeem tau txais qee qhov qauv dawb?

Yog lawm, peb muab cov qauv dawb ntawm Salicylic Acid Powder rau tus neeg siv khoom tab sis tus nqi thauj khoom yuav raug them los ntawm tus neeg siv khoom.

1. Yuav ua li cas them nyiaj thiab lub sijhawm them nyiaj yog dab tsi?

Kev them nyiaj tuaj yeem ua tiav los ntawm T / T, Credit Card, Western Union, PayPal thiab ntau dua.

3. Koj lub Hoobkas ua li cas kom paub tseeb tias cov khoom zoo?

Ua ntej tshaj plaws, peb muaj txog 10 xyoo kev paub hauv daim teb no, peb twb muaj cov txheej txheem tswj kom paub tab. Tsis tas li peb yuav kuaj zaum kawg ua ntej xa khoom kom tsis txhob muaj teeb meem.

4. Koj puas tuaj yeem ua OEM rau kuv?

Peb txais OEM xaj, tsuas yog tiv tauj peb thiab xa koj qhov kev thov rau peb. Peb yuav muab koj tus nqi tsim nyog thiab ua qauv ASAP.

5. Yuav tiv tauj peb li cas?

Koj tuaj yeem tham nrog peb los ntawm email, Skype thiab Whats-App lossis tsuas xa peb email, hu xov tooj. Tag nrho peb cov kev sib cuag tau pom hauv lub vev xaib.

Peb tuaj yeem muab feem ntau ntawm cov khoom xyaw tshuaj nquag (APIs) rau cov neeg siv khoom, Yog tias koj muaj lus nug lossis xav paub ntau ntxiv, thov hu rau peb ntawm E-mail:info@haozbio.com

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