Epoprostenol

1. Khoom npe: Eporostenol
2.Appearance: Dawb hmoov
3.Molecular Formula: C20H33NaO5
4.Molecular Luj: 376.47
5. CAS Nr.: 74610-55-2
6.Purity: 99%
7.Test Method: HPLC
8.Kev Them Nyiaj: TT, Western Union, Paypal, Pingpong, Xtransfer, ect.
9.Shelf Life: 2 xyoos

Xa kev nug Tsham tam sim no

Hauj lwm lawm

Khoom Taw Qhia

Epoprostenol sodium (Prostaglandin I2 sodium ntsev) yog ib daim ntawv hluavtaws ntawm prostaglandin I2, ib tug natural prostaglandin derivative, siv nyob rau hauv pulmonary arterial hypertension (PAH) kev tshawb fawb. Epoprostenol sodium yog siv los ua lub zog inhibitor ntawm platelet aggregation nyob rau hauv pulmonary arterial hypertension thiab transplantation.Prostacyclin yog ib tug antithrombin antagonist, thiab nws txo synthesis txhawb thrombosis.PGI2 muaj feem xyuam rau cov pharmacodynamic nyhuv ntawm cov tshuaj aspirin thiab lwm yam tshuaj antithrombotic, ua nyob rau hauv lub hlwb. cov hlab ntsha, nws muaj peev xwm tsis tsuas dilate cov hlab ntsha me me, tab sis kuj inhibit platelet aggregation, anti-thrombotic, inhibit qhov tso tawm ntawm inflammatory mediators, anti-remodeling.Epoprostenol tsis ruaj khov, nyob rau hauv vivo sai decomposition mus rau 6 ib-keto-PGF1 t. rau 2-3 feeb, nws cov metabolites ruaj khov dua, tab sis kev ua haujlwm lom neeg tsis muaj zog heev.

Product Photo thiab ua

Epoprostenol

Khoom Specification

Epoprostenol

Khoom muaj nuj nqi

Nws yog tsuas yog siv los ua tus neeg sawv cev antiplatelet los tiv thaiv hypercoagulability hauv kev kho mob ntawm qee yam kab mob plawv (xws li cardiopulmonary bypass, hemodialysis, thiab lwm yam). Nws kuj yog siv rau hauv cov kab mob loj heev peripheral vascular (xws li Raynaud's disease), kab mob plawv ischemic, thawj pulmonary hypertension thiab platelet-wasting kab mob.

Pharmacology thiab indications

Epoprostenol muaj antiplatelet thiab vasodilatory teebmeem, yog li nws tuaj yeem tiv thaiv thrombosis. Cov txheej txheem ntawm kev txiav txim ntawm yav dhau los yuav dag nyob rau hauv kev ua kom adenylate cyclase, uas ua rau kom cov concentration ntawm cAMP nyob rau hauv platelets.

Cov kev ceev faj

Feem ntau cov kev phiv tshwm sim muaj xws li hypotension, ceev lub plawv dhia, lub ntsej muag flushing, thiab mob taub hau, qhov tshwm sim ntawm uas nce nrog koob tshuaj. Tej zaum yuav muaj mob plab, xeev siab, ntuav, mob plab, nce ntshav qab zib, tsaug zog, mob hauv siab.

Kev siv thiab ntau npaum

Intravenous, 5mg / kg ib feeb, npaj thaum lub sij hawm kho mob hlwb siv, nruam drip lub sij hawm raws li tus mob.

Ntim

Sodium Eporostenol rau Txhaj Tshuaj: 500 8 ib qho tshuaj (nrog 50ml ntawm glycine tsis).

Kev faib tawm

Cov tshuaj hematologic

Kev mob tshwm sim thiab ceev faj

Muaj cov kev phiv xws li hypotension, plawv dhia ceev, lub ntsej muag yaug, thiab qee zaum plab hnyuv tsis xis nyob.

Prostacyclin (PGI 2) yog ib qho tshuaj tiv thaiv kab mob uas tau txais kev saib xyuas tshwj xeeb hauv xyoo tas los no, feem ntau yog tsim los ntawm cov hlwb endothelial, nrog rau cov vasodilating muaj zog thiab tiv thaiv platelet aggregation. Txo kev tsim cov prostacyclin tuaj yeem ua lub luag haujlwm tseem ceeb hauv xenograft thrombosis.

Khoom siv

Epoprostenol