Lomefloxacin

Khoom Taw Qhia

Lomefloxacin (lomefloxacin) tshuaj npe l-ethyl{1}}, 8-difluoro-1, 4-dihydro-7-(3-methyl-1-} piperazinyl)-4-oxo-3-quinolinecarboxylic acid, tawm-dawb mus rau daj crystals, molecular mis rau C17H19F2N3O3, molecular hnyav ntawm 351.34800, ntom ntawm 1.342 g / cm3, melting point {{21} ºC Kub taw tes ntawm 542.7 ºC ntawm 760 mmHg. 240ºC, boiling point 542.7ºC ntawm 760 mmHg, kho mob zoo nyob rau hauv urinary ib ntsuj av, ua pa ib ntsuj av tau thiab plab hnyuv kab mob.

 

Product Photo thiab ua

 

Khoom Specification

 

 

Khoom muaj nuj nqi

1. Nws yog ib tug ntev-acting quinolone qhov ncauj tshuaj tua kab mob. Nws exerts antibacterial nyhuv los ntawm inhibiting kab mob DNA gyrase thiab txwv tsis pub cov kab mob loj hlob. Nws muaj cov tshuaj tua kab mob dav dav, kev ua haujlwm siab, kev nyab xeeb, ruaj khov metabolism thiab ua siab ntev. Vim tias tsis muaj qhov cuam tshuam nrog theophylline, tsis muaj contraindication rau kev siv cov neeg mob hawb pob, yog li nws yog qhov tshwj xeeb tshaj yog rau kev siv cov neeg laus. Nws tuaj yeem siv rau cov kab mob ua pa, sepsis, enteritis, kab mob urinary, kab mob gynecological, kab mob qhov muag thiab qhov ncauj, thiab tseem tuaj yeem siv los tiv thaiv kab mob tom qab phais.
2. Siv los ua tshuaj tiv thaiv kab mob
3.Mainly siv nyob rau hauv kev kho mob ntawm tus kab mob thiab mob ntev los ntawm ntau yam kab mob gram-zoo thiab tsis zoo.

 

Txoj kev tsim khoom
Txoj Kev 1: 2,3,4-Trifluoronitrobenzene thiab RaneyNi tau yaj hauv ethanol thiab hydrogenated ntawm atmospheric siab. Cov catalyst tau lim tawm thiab muaj zog kom muab 2,3,4-trifluoroaniline (I) hauv 91.7% tawm los. Diethyl ethoxymethylene malonate (EMME) tau ntxiv rau (I) thiab ethoxymethylene malonate (EMME) thiab nplawm ntawm 140-150 degree . Cov txiaj ntsig ethanol tau evaporated, diphenylethane tau ntxiv, thiab cov tshuaj tiv thaiv tau nce mus rau 220 txog 240 degree mus txuas ntxiv. Lim thiab roj av ether ntxuav muab compound (II) hauv 88.3% tawm los. Rau kev sib xyaw ntawm cov khoom sib xyaw (Ⅱ), dimethylformamide thiab potassium carbonate, maj mam poob ethyl bromide hauv qab nplawm, thiab hnov ​​​​mob ntawm 50 ~ 60 degree. Txias rau hauv chav tsev kub, lim, concentrated thiab recrystallized nrog ethylene dichloride kom muab cov compound (III) hauv 90.3% yield. Boric acid thiab ethanoic anhydride, nplawm nyob rau hauv chav tsev kub thiab ces reflux cov tshuaj tiv thaiv. Txias, ntxiv cov khoom xyaw (III), 90 degree cov tshuaj tiv thaiv. Ntxiv dej, lim thiab ntxuav nrog dej kom tau qhov sib xyaw (IV) hauv 90.6% yield. Compound (IV), triethylamine thiab 2-methylpiperazine, chav ntsuas kub. Triethylamine tau zoo lawm, ethanol tau ntxiv thiab compound (V) tau los ntawm kev pom hauv 82.1% yield. Compound (V), 95% ethanol thiab triethylamine, reflux ua ke. Txias, lim cov khoom thiab ntxuav nrog me ntsis ethanol kom muab cov hmoov dawb crystalline lomefloxacin hauv 87.5% tawm los. Recrystallization nrog dimethylformamide muab xim tsis muaj koob zoo li crystalline lomefloxacin nrog melting point 241-241.9 degree . Cov crystalline lomefloxacin tau txais los ntawm kev ua kom rov ua dua tshiab nrog dimethylformamide. Lomefloxacin hydrochloride tau txais los ntawm txoj kev ib txwm muaj nyob rau hauv yuav luag ntau cov txiaj ntsig, thiab cov koob dawb zoo li tau txais los ntawm recrystallization nrog dej, melting point 296 ~ 300 degree. Txoj Kev 2: Siv 2,3,4,5-fluorobenzoic acid ua raw khoom, chlorinated los ntawm sulfoxide chloride rau chloride, ces condensed nrog diethyl ethoxy malonate, ces decarboxylated los tsim ethyl tetrafluorobenzoyl acetate, ces condensed nrog triethyl orthoform. Kev txiav txim ntawm acetic anhydride kom tau txais alkenyl daim ntawv cog lus, reacted nrog ethylamine los hloov ethoxy, thiab cyclized nyob rau hauv qhov kev txiav txim ntawm sodium hydride los tsim cov quinolinyl nplhaib derivatives, hydrolysis ntawm ester pab pawg neeg carboxyl, thiab thaum kawg reacted nrog {{38} } methylpiperazine muab lomefloxacin.2,3,4,5-Tetrafluorobenzoic acid tuaj yeem tau los ntawm cov tshuaj tiv thaiv hauv qab no.

 

Khoom siv

Nws yog qhov tsim nyog rau cov kab mob ua pa xws li mob hnyav ntawm cov kab mob ntsws ntev uas tshwm sim los ntawm cov kab mob rhiab heev, bronchial dilatation nrog kev kis kab mob, mob ntsws ntsws, mob ntsws thiab lwm yam kab mob ntawm cov kab mob genitourinary, kab mob plab, kab mob biliary, kab mob hauv plab, kab mob typhoid. cov nqaij mos ntawm daim tawv nqaij kab mob. Qhov ncauj lossis IV, 400-600mg ib hnub, qd-bid. chav kho mob txawv ntawm 3-14 hnub, raws li tus kab mob. Thaum siv los ua cov tshuaj prophylactic rau kev ua haujlwm transurethral thiab transrectal prostate biopsy, 400mg ib koob yuav tsum tau noj 1 ~ 6 teev ua ntej ua haujlwm. Kev kho tshuaj noj yog yuav tsum tau nyob rau hauv cov neeg mob uas lub raum insufficiency. Lomefloxacin tuaj yeem siv rau cov kab mob hauv qab no los ntawm cov kab mob rhiab heev:
(1) Cov kab mob genitourinary: suav nrog cov kab mob urinary yooj yim thiab nyuaj, mob prostatitis mob thiab mob ntev, gonococcal urethritis lossis cervicitis (xws li cov tshwm sim los ntawm enzyme-tsim hom), mob cystitis, mob pyelonephritis thiab lwm yam.
(2) Cov kab mob ua pa: nrog rau pharyngolaryngitis, tonsillitis, sinusitis, otitis media, mob exacerbation ntawm chronic bronchitis, mob exacerbation ntawm chronic obstructive pulmonary kab mob (cov ntaub ntawv txawv teb chaws), bronchodilatation nrog cov kab mob, mob bronchitis, li ntawd.
(3) Cov kab mob hauv plab: suav nrog enteritis, cholecystitis, perianal abscess, thiab lwm yam.
(4) Kev tiv thaiv kev phais mob (piv txwv li rau transrectal prostate puncture biopsy thiab urethra phais kom tiv thaiv kab mob urinary).
(5) Cov tshuaj no tuaj yeem siv rau kev kis kab mob sab nraud, xws li conjunctivitis, keratitis, corneal ulcers, dacryocystitis.
(6) Cov tshuaj pob ntseg no yog siv rau otitis media, otitis externa, tympanitis tshwm sim los ntawm cov kab mob rhiab heev.
(7) Lwm yam: mob typhoid kub taub hau, mob pob txha thiab pob qij txha, kab mob ntawm daim tawv nqaij thiab cov nqaij mos thiab cov kab mob hauv lub cev xws li sepsis.

 

Delivery & Ntim

Peb ib txwm ntim cov PS nrog cov ntawv ci hnab hmoov 1kg / hnab, export nruas 25kg / nruas.

Kuj lees txais kev pabcuam customization raws li koj qhov kev nug.

Raws li kev xa khoom, peb tuaj yeem xa khoom los ntawm courier, los ntawm hiav txwv, los ntawm huab cua, ect.

Xav paub ntau ntxiv thov mus saib cov duab hauv qab no rau kev siv:

 

Yog koj muaj lus nug los yog nug txogLomefloxacin, thov hu rau peb mail:info@haozbio.com

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